About Gene List

PF3D7_1140800

Genome location: Pf3D7_11_v3:1,633,071..1,636,567(+)

Genome classification: Core

Function and Localization

Product Description: CID domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.62 0.70
Trophozoite not expressed 0.59 0.66
Schizont possibly expressed 0.27 0.82
Gametocyte not expressed 0.41 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1140800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.134 | MFS: -2.921 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0908200)

  • Relative Growth Rate: 0.27 ± 0.14
  • Confidence: 5.39

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0908200)

Modification: Disrupted | RMgm-2510

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHV7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_153789

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 43 30 50
disruptive 18 87 61 152
missense 12 71 49 126

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 85 34 68
disruptive 39 236 127 297
missense 25 176 102 184

PlasmoDB Total SNPs: 122

Non-coding: 55 | Synonymous: 31 | Nonsynonymous: 36 | Stop Codon: 0

Protein Information

Protein Length: 803 | Molecular Weight (kDa): 95.466

UniProt ID(s): Q8IHV7

PDB ID(s): None

Isoelectric Point: 6.23

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108