About Gene List

PF3D7_1140900

Genome location: Pf3D7_11_v3:1,636,768..1,643,539(-)

Genome classification: Core

Function and Localization

Product Description: NdP1 protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite possibly expressed 0.39 0.77
Schizont expressed 0.25 0.85
Gametocyte possibly expressed 0.33 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1140900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.074 | #Insertions: 0

PlasmoGEM Phenotype: Insufficient data (Pb ortholog: PBANKA_0908100)

  • Relative Growth Rate: 0.68 ± 1.11
  • Confidence: 1.19

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHV6

"Best" AlphaFill ligand hit: NOS (inosine, Local RMSD=9.91) with 7R3A (Global RMSD=18.03)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532719

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 16 87 48 127
disruptive 48 183 127 244
missense 48 180 122 230

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 25 167 79 135
disruptive 86 388 185 366
missense 76 352 170 293

PlasmoDB Total SNPs: 328

Non-coding: 200 | Synonymous: 71 | Nonsynonymous: 57 | Stop Codon: 0

Protein Information

Protein Length: 1788 | Molecular Weight (kDa): 215.389

UniProt ID(s): Q8IHV6

PDB ID(s): None

Isoelectric Point: 8.4

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
33495622 An Alveolata secretory machinery adapted to parasite host cell invasion. Aquilini E, Cova MM, ..., Lebrun M 10.1038/s41564-020-00854-z