PF3D7_1141000

Genome location: Pf3D7_11_v3:1,644,911..1,647,382(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.06	0.97
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.32	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1141000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.578 | MFS: -2.461 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHV5

"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=18.85) with 3JQQ (Global RMSD=40.62)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532424

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	30	25	47
disruptive	20	131	83	175
missense	17	113	79	157

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	80	28	60
disruptive	68	292	135	223
missense	44	252	121	171

PlasmoDB Total SNPs: 97

Non-coding: 0 | Synonymous: 58 | Nonsynonymous: 38 | Stop Codon: 1

Protein Information

Protein Length: 823 | Molecular Weight (kDa): 99.655

UniProt ID(s): Q8IHV5

PDB ID(s): None

Isoelectric Point: 10.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A