PF3D7_1141100

Genome location: Pf3D7_11_v3:1,649,321..1,657,012(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	not expressed	0.07	0.96
Schizont	not expressed	0.03	0.98
Gametocyte	possibly expressed	1.09	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1141100

Resistome Missense Mutations: N324H, K2046N

Resistome Compounds with Missense Mutations: Lopinavir, MMV023367

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.393 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHV4

"Best" AlphaFill ligand hit: DTP (, Local RMSD=5.53) with 2JAS (Global RMSD=12.86)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_118471

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	23	117	73	148
disruptive	110	462	253	635
missense	76	379	222	547

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	35	234	97	174
disruptive	250	921	418	805
missense	155	769	362	571

PlasmoDB Total SNPs: 301

Non-coding: 0 | Synonymous: 159 | Nonsynonymous: 141 | Stop Codon: 1

Protein Information

Protein Length: 2563 | Molecular Weight (kDa): 304.041

UniProt ID(s): Q8IHV4

PDB ID(s): None

Isoelectric Point: 9.54

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A