About Gene List

PF3D7_1141200

Genome location: Pf3D7_11_v3:1,657,118..1,658,339(-)

Genome classification: Core

Function and Localization

Product Description: ATP synthase-associated protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.00 1.00
Trophozoite expressed 0.02 0.99
Schizont expressed 0.01 0.99
Gametocyte expressed 0.03 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1141200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0907800)

  • Relative Growth Rate: 0.88 ± 0.13
  • Confidence: 5.47

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0907800)

Modification: Disrupted | RMgm-2509

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A102

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139432

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 62

Non-coding: 61 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 111 | Molecular Weight (kDa): 13.325

UniProt ID(s): A0A144A102

PDB ID(s): None

Isoelectric Point: 10.48

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
27594426 A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential ApicomplexanGenes. Sidik SM, Huet D, ..., Lourido S 10.1016/j.cell.2016.08.019
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21