Genome location: Pf3D7_11_v3:1,658,390..1,663,036(-)
Genome classification: Core
Product Description: apical polar ring protein APR1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020007 | apical complex |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 1.04 | 0.50 |
| Schizont | expressed | 0.86 | 0.58 |
| Gametocyte | expressed | 1.16 | 0.43 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1141300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.05 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0907700)
Modification: Tagged | RMgm-4952
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHV2
"Best" AlphaFill ligand hit: TAM (tris(hydroxyethyl)aminomethane, Local RMSD=0.10) with 2YP2 (Global RMSD=28.48)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 58 | 32 | 70 |
| disruptive | 22 | 113 | 67 | 178 |
| missense | 19 | 108 | 61 | 160 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 107 | 41 | 77 |
| disruptive | 54 | 264 | 135 | 291 |
| missense | 39 | 224 | 119 | 230 |
PlasmoDB Total SNPs: 218
Non-coding: 144 | Synonymous: 35 | Nonsynonymous: 39 | Stop Codon: 0
Protein Length: 1012 | Molecular Weight (kDa): 120.381
UniProt ID(s): Q8IHV2
PDB ID(s): None
Isoelectric Point: 9.63
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | SSF50729 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 33705380 | Molecular characterization of the conoid complex in Toxoplasma reveals itsconservation in all apicomplexans, including Plasmodium species. | Koreny L, Zeeshan M, ..., Waller RF | 10.1371/journal.pbio.3001081 |
| 37018283 | High prevalence of malaria in pregnancy among women attending antenatal care at alarge referral hospital in northwestern Uganda: A cross-sectional study | Mangusho C, Mwebesa E, ..., Legason ID | 10.1371/journal.pone.0283755 |
| 28331073 | Stability and function of a putative microtubule-organizing center in the humanparasite Toxoplasma gondii | Leung JM, He Y, ..., Hu K | 10.1091/mbc.E17-01-0045 |