PF3D7_1141500

Genome location: Pf3D7_11_v3:1,665,761..1,668,162(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.00	1.00
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.01	0.99
Gametocyte	not expressed	0.36	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1141500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.608 | MFS: -2.703 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHV0

"Best" AlphaFill ligand hit: APC (alpha,beta-methyleneadenosine-5'-triphosphate, Local RMSD=0.46) with 4EWV (Global RMSD=21.30)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532644

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	30	11	25
disruptive	6	24	26	46
missense	6	22	25	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	42	22	22
disruptive	15	79	44	81
missense	10	59	40	60

PlasmoDB Total SNPs: 181

Non-coding: 159 | Synonymous: 16 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 303 | Molecular Weight (kDa): 36.507

UniProt ID(s): Q8IHV0

PDB ID(s): None

Isoelectric Point: 9.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A