PF3D7_1141700

Genome location: Pf3D7_11_v3:1,669,907..1,671,894(+)

Genome classification: Core

Function and Localization

Product Description: OTU domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0004843	thiol-dependent deubiquitinase
Process	GO:0016579	protein deubiquitination

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.11	0.95
Trophozoite	not expressed	0.52	0.70
Schizont	possibly expressed	0.09	0.94
Gametocyte	possibly expressed	0.16	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1141700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -2.867 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHU8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102788

Most Similar Human Ortholog: Q8N6M0

TM-align score: 0.51 | RMSD: 3.03

Seq Identity: 0.29 | Length: 166 / 313

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000155100	OTU deubiquitinase 6B

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	10	17	28
disruptive	2	42	26	57
missense	2	41	26	55

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	31	18	26
disruptive	6	86	50	99
missense	5	73	46	67

PlasmoDB Total SNPs: 150

Non-coding: 139 | Synonymous: 7 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 313 | Molecular Weight (kDa): 37.664

UniProt ID(s): Q8IHU8

PDB ID(s): None

Isoelectric Point: 5.37

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003323	OTU domain
InterPro	IPR038765	Papain-like cysteine peptidase superfamily
PFam	PF02338	OTU domain
Superfamily	SSF54001	Papain-like cysteine peptidase superfamily