PF3D7_1141800

Genome location: Pf3D7_11_v3:1,672,402..1,675,566(-)

Genome classification: Core

Function and Localization

Product Description: EELM2 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	expressed	0.17	0.90
Schizont	expressed	0.87	0.56
Gametocyte	expressed	0.24	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1141800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.993 | MFS: -2.659 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1234600)

Relative Growth Rate: 0.10 ± 0.15
Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHU7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134709

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	29	19	33
disruptive	4	17	20	35
missense	4	15	16	28

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	56	27	33
disruptive	8	56	46	106
missense	4	45	38	77

PlasmoDB Total SNPs: 174

Non-coding: 148 | Synonymous: 24 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 394 | Molecular Weight (kDa): 46.666

UniProt ID(s): Q8IHU7

PDB ID(s): None

Isoelectric Point: 6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019786	Zinc finger, PHD-type, conserved site
InterPro	IPR019787	Zinc finger, PHD-finger
InterPro	IPR031724	Extended EGL-27 and MTA1 homology domain
InterPro	IPR042163	PHD finger protein 12
PFam	PF00628	Zinc finger, PHD-finger
PFam	PF15863	Extended EGL-27 and MTA1 homology domain
Superfamily	SSF57903	Zinc finger, FYVE/PHD-type

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
19765590	Potential epigenetic regulatory proteins localise to distinct nuclearsub-compartments in Plasmodium falciparum.	Volz J, Carvalho TG, ..., Cowman AF	10.1016/j.ijpara.2009.09.002
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108