Genome location: Pf3D7_11_v3:1,676,182..1,677,783(-)
Genome classification: Core
Product Description: inner membrane complex protein 1b, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070258 | inner membrane pellicle complex |
| Function | GO:0005200 | structural constituent of cytoskeleton |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.02 | 0.99 |
| Schizont | not expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 1.25 | 0.59 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1141900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.121 | #Insertions: 4
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0907100)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0907100)
Modification: Disrupted | RMgm-2507
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHU6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 30 | 23 | 38 |
| disruptive | 16 | 46 | 32 | 98 |
| missense | 15 | 45 | 30 | 88 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 66 | 25 | 30 |
| disruptive | 29 | 135 | 64 | 172 |
| missense | 24 | 123 | 54 | 105 |
PlasmoDB Total SNPs: 33
Non-coding: 2 | Synonymous: 17 | Nonsynonymous: 14 | Stop Codon: 0
Protein Length: 504 | Molecular Weight (kDa): 59.606
UniProt ID(s): Q8IHU6
PDB ID(s): None
Isoelectric Point: 6.09
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR022086 | Inner membrane complex protein |
| PFam | PF12314 | Inner membrane complex protein |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 18650444 | IMC1b is a putative membrane skeleton protein involved in cell shape, mechanicalstrength, motility, and infectivity of malaria ookinetes. | Tremp AZ, Khater EI, Dessens JT | 10.1074/jbc.M801302200 |
| 21098480 | Malaria IMC1 membrane skeleton proteins operate autonomously and participate inmotility independently of cell shape | Tremp AZ, Dessens JT | 10.1074/jbc.M110.187195 |