PF3D7_1142000

Genome location: Pf3D7_11_v3:1,678,820..1,681,377(+)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	expressed	0.24	0.86
Schizont	not expressed	0.02	0.99
Gametocyte	possibly expressed	0.32	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1142000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.148 | MFS: -2.895 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHU5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533498

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	28	17	51
disruptive	14	100	68	150
missense	14	98	65	141

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	70	30	64
disruptive	32	253	100	217
missense	27	231	89	156

PlasmoDB Total SNPs: 73

Non-coding: 29 | Synonymous: 22 | Nonsynonymous: 22 | Stop Codon: 0

Protein Information

Protein Length: 692 | Molecular Weight (kDa): 82.504

UniProt ID(s): Q8IHU5

PDB ID(s): None

Isoelectric Point: 9.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A