PF3D7_1142100

Genome location: Pf3D7_11_v3:1,681,435..1,692,161(-)

Genome classification: Core

Function and Localization

Product Description: DnaJ domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	2.01	0.29
Trophozoite	possibly expressed	1.38	0.39
Schizont	expressed	1.14	0.50
Gametocyte	possibly expressed	1.56	0.31

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1142100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.661 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533419

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	32	162	89	192
disruptive	130	509	279	633
missense	68	390	231	530

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	66	306	121	194
disruptive	253	978	446	808
missense	134	756	367	568

PlasmoDB Total SNPs: 465

Non-coding: 149 | Synonymous: 187 | Nonsynonymous: 129 | Stop Codon: 0

Protein Information

Protein Length: 2738 | Molecular Weight (kDa): 324.826

UniProt ID(s): Q8IHU4

PDB ID(s): None

Isoelectric Point: 5.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001623	DnaJ domain
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
InterPro	IPR036869	Chaperone J-domain superfamily
PFam	N/A	N/A
Superfamily	SSF46565	Chaperone J-domain superfamily
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108