PF3D7_1142200

Genome location: Pf3D7_11_v3:1,692,791..1,694,345(-)

Genome classification: Core

Function and Localization

Product Description: vacuolar protein sorting-associated protein IST1-like, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.12	0.92
Schizont	not expressed	0.04	0.97
Gametocyte	not expressed	0.12	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1142200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.695 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHU3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102849

Most Similar Human Ortholog: H3BQ38

TM-align score: 0.84 | RMSD: 1.28

Seq Identity: 0.03 | Length: 37 / 272

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000182149	IST1 factor associated with ESCRT-III

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	16	12	24
disruptive	6	28	19	49
missense	5	26	19	45

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	29	11	26
disruptive	10	76	36	82
missense	7	61	27	48

PlasmoDB Total SNPs: 99

Non-coding: 89 | Synonymous: 5 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 272 | Molecular Weight (kDa): 32.612

UniProt ID(s): Q8IHU3

PDB ID(s): None

Isoelectric Point: 9.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A