About Gene List

PF3D7_1142300

Genome location: Pf3D7_11_v3:1,694,889..1,701,865(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.33 0.84
Trophozoite expressed 0.96 0.51
Schizont expressed 1.60 0.28
Gametocyte expressed 1.02 0.48

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1142300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.532 | MFS: -2.432 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHU2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533249

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 19 103 55 136
disruptive 60 292 161 363
missense 42 250 148 314

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 34 193 95 146
disruptive 113 573 245 455
missense 78 481 209 345

PlasmoDB Total SNPs: 303

Non-coding: 136 | Synonymous: 83 | Nonsynonymous: 84 | Stop Codon: 0

Protein Information

Protein Length: 1828 | Molecular Weight (kDa): 215.982

UniProt ID(s): Q8IHU2

PDB ID(s): None

Isoelectric Point: 9.21

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097