Genome location: Pf3D7_11_v3:1,705,435..1,706,918(-)
Genome classification: Core
Product Description: 60S ribosomal protein L28
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.81 | 0.63 |
| Trophozoite | expressed | 1.52 | 0.32 |
| Schizont | expressed | 0.17 | 0.90 |
| Gametocyte | possibly expressed | 0.71 | 0.62 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1142500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.147 | MFS: -3.434 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHU0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102892
Most Similar Human Ortholog: H0YKD8
TM-align score: 0.76 | RMSD: 2.55
Seq Identity: 0.15 | Length: 119 / 127
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000108107 | ribosomal protein L28 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 13 | 3 | 12 |
| disruptive | 4 | 7 | 9 | 11 |
| missense | 4 | 7 | 9 | 8 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 19 | 10 | 8 |
| disruptive | 9 | 21 | 12 | 32 |
| missense | 6 | 18 | 10 | 23 |
PlasmoDB Total SNPs: 115
Non-coding: 107 | Synonymous: 5 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 127 | Molecular Weight (kDa): 14.407
UniProt ID(s): Q8IHU0
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 10.89
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002672 | Ribosomal protein L28e |
| InterPro | IPR029004 | Ribosomal L28e/Mak16 |
| PFam | PF01778 | Ribosomal L28e/Mak16 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 37358297 | Redefining pleiotropic drug resistance in a pathogenic yeast: Pdr1 functions as asensor of cellular stresses in Candida glabrata | Gale AN, Pavesic MW, ..., Cunningham KW | 10.1128/msphere.00254-23 |
| 37214952 | Redefining Pleiotropic Drug Resistance in a Pathogenic Yeast: Pdr1 Functions as aSensor of Cellular Stresses in Candida glabrata | Gale AN, Pavesic MW, ..., Cunningham KW | 10.1101/2023.05.07.539747 |