Genome location: Pf3D7_11_v3:1,713,070..1,714,304(+)
Genome classification: Core
Product Description: ATP synthase-associated protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Process | GO:0015986 | ATP synthesis coupled proton transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.09 | 0.96 |
| Trophozoite | expressed | 0.38 | 0.76 |
| Schizont | possibly expressed | 0.13 | 0.91 |
| Gametocyte | possibly expressed | 0.40 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1142800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.171 | MFS: -2.815 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0906200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0906200)
Modification: Disrupted | RMgm-2502
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHT7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 22 | 9 | 17 |
| disruptive | 4 | 22 | 15 | 41 |
| missense | 2 | 19 | 12 | 32 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 38 | 15 | 15 |
| disruptive | 11 | 57 | 28 | 88 |
| missense | 4 | 44 | 18 | 63 |
PlasmoDB Total SNPs: 89
Non-coding: 46 | Synonymous: 39 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 297 | Molecular Weight (kDa): 35.453
UniProt ID(s): Q8IHT7
PDB ID(s): None
Isoelectric Point: 8.39
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30005062 | Highly diverged novel subunit composition of apicomplexan F-type ATP synthaseidentified from Toxoplasma gondii. | Salunke R, Mourier T, ..., Shanmugam D | 10.1371/journal.pbio.2006128 |
| 31390575 | Landscape of the Plasmodium Interactome Reveals Both Conserved andSpecies-Specific Functionality. | Hillier C, Pardo M, ..., Choudhary JS | 10.1016/j.celrep.2019.07.019 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |