PF3D7_1142900

Genome location: Pf3D7_11_v3:1,714,779..1,717,145(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.11	0.93
Schizont	possibly expressed	0.89	0.54
Gametocyte	expressed	0.31	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1142900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.238 | MFS: -2.647 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0906100)

Relative Growth Rate: 0.74 ± 0.11
Confidence: 5.88

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0906100)

Modification: Disrupted | RMgm-2501

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHT6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532690

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	19	11	33
disruptive	9	58	39	79
missense	8	56	36	72

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	36	21	39
disruptive	30	123	62	129
missense	19	115	53	95

PlasmoDB Total SNPs: 147

Non-coding: 111 | Synonymous: 15 | Nonsynonymous: 20 | Stop Codon: 1

Protein Information

Protein Length: 507 | Molecular Weight (kDa): 61.341

UniProt ID(s): Q8IHT6

PDB ID(s): None

Isoelectric Point: 10.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21