Product Description: alpha/beta hydrolase, putative
SignalP Peptide: MPILFYIFYIFCFPLINLS
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.02 | 0.99 |
| Trophozoite | no data | 0.15 | 0.90 |
| Schizont | no data | 0.06 | 0.96 |
| Gametocyte | no data | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1143000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -3.126 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0906000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0906000)
Modification: Disrupted | RMgm-2500
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3G2
"Best" AlphaFill ligand hit: BEZ (benzoic acid, Local RMSD=0.06) with 1UKB (Global RMSD=2.32)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q8NFV4 | Protein ABHD11 | OrthoDB, OrthoMCL BLAST | CHEMBL1891894CHEMBL1903566CHEMBL3133033 |
Ortholog Group (OrthoMCL): OG6_101420
Most Similar Human Ortholog: Q8NFV4
TM-align score: 0.79 | RMSD: 2.77
Seq Identity: 0.27 | Length: 277 / 382
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000106077 | abhydrolase domain containing 11 |
Protein Length: 382 | Molecular Weight (kDa): 44.754
UniProt ID(s): C6S3G2
PDB ID(s): None
Isoelectric Point: 9.21
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000073 | Alpha/beta hydrolase fold-1 |
| InterPro | IPR029058 | Alpha/Beta hydrolase fold |
| PFam | PF00561 | Alpha/beta hydrolase fold-1 |
| Superfamily | SSF53474 | Alpha/Beta hydrolase fold |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 25 | 21 | 31 |
| disruptive | 3 | 39 | 22 | 48 |
| missense | 3 | 38 | 22 | 42 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 52 | 26 | 20 |
| disruptive | 10 | 79 | 42 | 86 |
| missense | 10 | 74 | 39 | 58 |
PlasmoDB Total SNPs: 34
Non-coding: 9 | Synonymous: 16 | Nonsynonymous: 9 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |