About Gene List

PF3D7_1143200

Genome location: Pf3D7_11_v3:1,728,890..1,731,885(+)

Genome classification: Core

Function and Localization

Product Description: DnaJ protein, putative

SignalP Peptide: MRIHCFSFVLLYFLFVNNVNC

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005789 endoplasmic reticulum membrane
Process GO:0006457 protein folding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.04 0.98
Trophozoite expressed 0.32 0.82
Schizont expressed 0.77 0.62
Gametocyte expressed 0.27 0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1143200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.058 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0905800)

Modification: Disrupted | RMgm-494

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHT4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt Protein Name Species Homology Source BindingDB Ligands
P31689 DnaJ homolog subfamily A member 1 Homo sapiens OrthoDB CHEMBL52073CHEMBL159171

Orthology Information

Ortholog Group (OrthoMCL): OG6_105648

Most Similar Human Ortholog: Q9H1X3

TM-align score: 0.56 | RMSD: 4.37

Seq Identity: 0.20 | Length: 236 / 321

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000059769 DnaJ heat shock protein family (Hsp40) member C25

Protein Information

Protein Length: 321 | Molecular Weight (kDa): 39.362

UniProt ID(s): Q8IHT4

PDB ID(s): None

Isoelectric Point: 10.16

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001623 DnaJ domain
InterPro IPR036869 Chaperone J-domain superfamily
PFam PF00226 DnaJ domain
Superfamily SSF46565 Chaperone J-domain superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 261

Non-coding: 246 | Synonymous: 5 | Nonsynonymous: 10 | Stop Codon: 0

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104