PF3D7_1143400

Genome location: Pf3D7_11_v3:1,733,903..1,736,776(+)

Genome classification: Core

Function and Localization

Product Description: translation initiation factor eIF-1A, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016282	eukaryotic 43S preinitiation complex
Function	GO:0003743	translation initiation factor activity
Process	GO:0006413	translational initiation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.24	0.88
Trophozoite	expressed	0.68	0.62
Schizont	expressed	0.45	0.72
Gametocyte	expressed	0.33	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1143400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.978 | MFS: -2.774 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHT2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100738

Most Similar Human Ortholog: X6RAC9

TM-align score: 0.78 | RMSD: 2.31

Seq Identity: 0.72 | Length: 101 / 155

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000173674	eukaryotic translation initiation factor 1A X-linked
ENSG00000198692	eukaryotic translation initiation factor 1A Y-linked

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	7	8	14
disruptive	1	0	1	3
missense	1	0	1	2

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	22	10	12
disruptive	1	9	14	48
missense	1	5	10	36

PlasmoDB Total SNPs: 212

Non-coding: 200 | Synonymous: 12 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 155 | Molecular Weight (kDa): 17.867

UniProt ID(s): Q8IHT2

PDB ID(s): None

Isoelectric Point: 4.9

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001253	Translation initiation factor 1A (eIF-1A)
InterPro	IPR006196	RNA-binding domain, S1, IF1 type
InterPro	IPR012340	Nucleic acid-binding, OB-fold
InterPro	IPR018104	Translation initiation factor 1A (eIF-1A), conserved site
PFam	PF01176	RNA-binding domain, S1, IF1 type
Superfamily	SSF50249	Nucleic acid-binding, OB-fold