PF3D7_1143500

Genome location: Pf3D7_11_v3:1,736,787..1,740,230(-)

Genome classification: Core

Function and Localization

Product Description: regulator of chromosome condensation, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005739	mitochondrion
Function	GO:0003682	chromatin binding
Process	GO:0031291	Ran protein signal transduction
Process	GO:1901673	regulation of mitotic spindle assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.14	0.93
Trophozoite	expressed	0.97	0.54
Schizont	expressed	1.08	0.48
Gametocyte	expressed	1.74	0.31

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1143500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.116 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHT1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533601

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	47	27	64
disruptive	50	182	83	171
missense	35	148	74	137

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	86	53	63
disruptive	103	330	143	267
missense	67	261	118	173

PlasmoDB Total SNPs: 265

Non-coding: 127 | Synonymous: 61 | Nonsynonymous: 77 | Stop Codon: 0

Protein Information

Protein Length: 878 | Molecular Weight (kDa): 105.891

UniProt ID(s): Q8IHT1

PDB ID(s): None

Isoelectric Point: 10.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000408	Regulator of chromosome condensation, RCC1
InterPro	IPR009091	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
PFam	PF13540	N/A
Superfamily	SSF50985	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21