PF3D7_1143600

Genome location: Pf3D7_11_v3:1,740,858..1,742,152(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.03	0.99
Schizont	not expressed	0.06	0.96
Gametocyte	expressed	0.97	0.52

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1143600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.907 | MFS: -2.266 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHT0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532585

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	14	5	15
disruptive	12	42	31	56
missense	8	30	27	43

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	26	13	12
disruptive	28	113	37	89
missense	13	76	33	68

PlasmoDB Total SNPs: 153

Non-coding: 76 | Synonymous: 61 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 297 | Molecular Weight (kDa): 35.126

UniProt ID(s): Q8IHT0

PDB ID(s): None

Isoelectric Point: 5.93

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A