PF3D7_1143700

Genome location: Pf3D7_11_v3:1,742,517..1,746,755(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.07	0.96
Schizont	not expressed	0.08	0.95
Gametocyte	possibly expressed	0.74	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1143700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.985 | MFS: -2.702 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0905300)

Relative Growth Rate: 1.04 ± 0.14
Confidence: 5.26

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0905300)

Modification: Disrupted | RMgm-2498

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHS8

"Best" AlphaFill ligand hit: 4BW (2-amino-9-[(2r,3r,3as,5r,7ar,9r,10r,10as,12r,14ar)-9-(6-amino-9h-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2h,7h-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6h-purin-6-one, Local RMSD=10.71) with 6WT4 (Global RMSD=14.26)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533337

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	49	27	64
disruptive	9	112	81	151
missense	9	111	80	143

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	19	80	48	68
disruptive	27	275	115	254
missense	26	247	90	180

PlasmoDB Total SNPs: 386

Non-coding: 322 | Synonymous: 44 | Nonsynonymous: 20 | Stop Codon: 0

Protein Information

Protein Length: 856 | Molecular Weight (kDa): 104.129

UniProt ID(s): Q8IHS8

PDB ID(s): None

Isoelectric Point: 7.55

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094