Genome location: Pf3D7_11_v3:1,747,226..1,751,441(+)
Genome classification: Core
Product Description: oocyst capsule protein Cap93, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.64 | 0.69 |
| Trophozoite | possibly expressed | 0.31 | 0.82 |
| Schizont | possibly expressed | 0.18 | 0.90 |
| Gametocyte | possibly expressed | 0.28 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1143800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.012 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0905200)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0905200)
Modification: Disrupted | RMgm-4312
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHS7
"Best" AlphaFill ligand hit: DXC ((3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oic acid, Local RMSD=0.26) with 4QN9 (Global RMSD=5.66)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q8BH82 | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D | OrthoDB, OrthoMCL BLAST | CHEMBL4790197CHEMBL4782800CHEMBL4754918CHEMBL4780517... | |
| Q6IQ20 | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D | OrthoDB, OrthoMCL BLAST | CHEMBL4790197CHEMBL4762175CHEMBL4791170CHEMBL4778789... |
Ortholog Group (OrthoMCL): OG6_102519
Most Similar Human Ortholog: Q6IQ20
TM-align score: 0.82 | RMSD: 2.49
Seq Identity: 0.35 | Length: 349 / 899
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000161048 | N-acyl phosphatidylethanolamine phospholipase D |
| ENSG00000275723 | N-acyl phosphatidylethanolamine phospholipase D |
Protein Length: 899 | Molecular Weight (kDa): 106.721
UniProt ID(s): Q8IHS7
PDB ID(s): None
Isoelectric Point: 9.27
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001279 | Metallo-beta-lactamase |
| InterPro | IPR036866 | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
| PFam | PF12706 | Metallo-beta-lactamase |
| Superfamily | SSF56281 | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 61 | 27 | 70 |
| disruptive | 22 | 77 | 51 | 115 |
| missense | 15 | 66 | 44 | 98 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 123 | 47 | 52 |
| disruptive | 41 | 174 | 91 | 187 |
| missense | 27 | 130 | 77 | 114 |
PlasmoDB Total SNPs: 265
Non-coding: 186 | Synonymous: 46 | Nonsynonymous: 33 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 28841886 | Plasmodium berghei Cap93, a novel oocyst capsule-associated protein, plays a rolein sporozoite development | Sasaki H, Sekiguchi H, Sugiyama M, Ikadai H | 10.1186/s13071-017-2337-8 |