Genome location: Pf3D7_11_v3:1,754,466..1,756,072(+)
Genome classification: Core
Product Description: 40S ribosomal protein S21
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Process | GO:0000461 | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.20 | 0.90 |
| Trophozoite | expressed | 0.32 | 0.80 |
| Schizont | possibly expressed | 0.05 | 0.96 |
| Gametocyte | possibly expressed | 0.12 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1144000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.776 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0905000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHS5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101819
Most Similar Human Ortholog: Q8WVC2
TM-align score: 0.95 | RMSD: 0.68
Seq Identity: 0.46 | Length: 80 / 82
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000171858 | ribosomal protein S21 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 4 | 6 | 6 |
| disruptive | 0 | 0 | 1 | 4 |
| missense | 0 | 0 | 1 | 4 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 12 | 8 | 6 |
| disruptive | 0 | 3 | 5 | 27 |
| missense | 0 | 3 | 4 | 18 |
PlasmoDB Total SNPs: 73
Non-coding: 73 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 82 | Molecular Weight (kDa): 9.145
UniProt ID(s): Q8IHS5
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 8.5
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001931 | Ribosomal protein S21e |
| PFam | PF01249 | Ribosomal protein S21e |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 34934010 | Release of the ribosome biogenesis factor Bud23 from small subunit precursors inyeast | Black JJ, Johnson AW | 10.1261/rna.079025.121 |
| 36996028 | Impact of the yeast S0/uS2-cluster ribosomal protein rpS21/eS21 on rRNA foldingand the architecture of small ribosomal subunit precursors | Poll G, Griesenbeck J, Tschochner H, Milkereit P | 10.1371/journal.pone.0283698 |