Product Description: mitochondrial large subunit ribosomal protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003735 | structural constituent of ribosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.04 | 0.98 |
| Trophozoite | no data | 0.31 | 0.80 |
| Schizont | no data | 0.09 | 0.94 |
| Gametocyte | no data | 0.40 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1144100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.222 | MFS: -4.036 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZZH9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104265
Most Similar Human Ortholog: Q13405
TM-align score: 0.67 | RMSD: 2.58
Seq Identity: 0.25 | Length: 97 / 123
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000149792 | mitochondrial ribosomal protein L49 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 7 | 4 | 16 |
| disruptive | 0 | 3 | 5 | 6 |
| missense | 0 | 3 | 4 | 6 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 19 | 9 | 4 |
| disruptive | 2 | 11 | 9 | 30 |
| missense | 0 | 9 | 7 | 24 |
PlasmoDB Total SNPs: 53
Non-coding: 42 | Synonymous: 11 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 123 | Molecular Weight (kDa): 14.5
UniProt ID(s): A0A143ZZH9
PDB ID(s): None
Isoelectric Point: 10.87
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007740 | Ribosomal protein L49/IMG2 |
| PFam | PF05046 | Ribosomal protein L49/IMG2 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |