PF3D7_1144200

Genome location: Pf3D7_11_v3:1,757,488..1,759,205(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.13	0.94
Trophozoite	not expressed	0.16	0.90
Schizont	not expressed	0.06	0.97
Gametocyte	not expressed	0.79	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1144200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.008 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A139

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533030

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	21	10	21
disruptive	14	73	41	72
missense	9	70	36	64

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	39	11	33
disruptive	34	155	54	96
missense	22	131	43	73

PlasmoDB Total SNPs: 111

Non-coding: 71 | Synonymous: 18 | Nonsynonymous: 22 | Stop Codon: 0

Protein Information

Protein Length: 319 | Molecular Weight (kDa): 37.596

UniProt ID(s): A0A144A139, Q8IHS4

PDB ID(s): None

Isoelectric Point: 9.62

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A