About Gene List

PF3D7_1144300 (RPL41)

Genome location: Pf3D7_11_v3:1,759,227..1,760,663(-)

Genome classification: Core

Function and Localization

Product Description: 60S ribosomal protein L41

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0022625 cytosolic large ribosomal subunit

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.14 0.93
Trophozoite no data 0.25 0.84
Schizont no data 0.04 0.97
Gametocyte no data 0.10 0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1144300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: N/A

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3G4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532918

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 132

Non-coding: 130 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 39 | Molecular Weight (kDa): 5.086

UniProt ID(s): C6S3G4

PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD

Isoelectric Point: 13.16

Protein Domain Annotations:

Source Family ID Description
InterPro IPR007836 Ribosomal protein L41
PFam PF05162 Ribosomal protein L41
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
24913268 Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine Wong W, Bai XC, ..., Scheres SH 10.7554/eLife.03080
29192585 Yeast eIF4A enhances recruitment of mRNAs regardless of their structuralcomplexity Yourik P, Aitken CE, ..., Lorsch JR 10.7554/eLife.31476