PF3D7_1144400

Genome location: Pf3D7_11_v3:1,762,256..1,766,650(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.20	0.91
Trophozoite	not expressed	0.18	0.90
Schizont	not expressed	0.05	0.97
Gametocyte	possibly expressed	0.74	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1144400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.314 | #Insertions: 3

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1446500)

Relative Growth Rate: 0.05 ± 0.05
Confidence: 7.48

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0904600)

Modification: Disrupted | RMgm-2494

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHS3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110457

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	81	59	95
disruptive	75	371	151	379
missense	50	313	138	318

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	36	151	73	99
disruptive	177	655	234	481
missense	112	544	195	333

PlasmoDB Total SNPs: 221

Non-coding: 0 | Synonymous: 100 | Nonsynonymous: 119 | Stop Codon: 2

Protein Information

Protein Length: 1464 | Molecular Weight (kDa): 175.411

UniProt ID(s): Q8IHS3

PDB ID(s): None

Isoelectric Point: 6.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A