Genome location: Pf3D7_11_v3:1,767,459..1,769,954(+)
Genome classification: Core
Product Description: SUMO-activating enzyme subunit 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031510 | SUMO activating enzyme complex |
| Component | GO:0005737 | cytoplasm |
| Function | GO:0019948 | SUMO activating enzyme activity |
| Process | GO:0032446 | protein modification by small protein conjugation |
| Process | GO:0016925 | protein sumoylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.32 | 0.80 |
| Schizont | expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 0.20 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1144500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.154 | MFS: -2.669 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0904500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHS2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9UBE0 | SUMO-activating enzyme subunit 1/2 | OMA, OrthoDB | MLS000068755MLS000079922MLS000042514MLS000053822... |
Ortholog Group (OrthoMCL): OG6_102966
Most Similar Human Ortholog: M0R286
TM-align score: 0.85 | RMSD: 1.66
Seq Identity: 0.19 | Length: 98 / 338
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000142230 | SUMO1 activating enzyme subunit 1 |
Protein Length: 338 | Molecular Weight (kDa): 39.689
UniProt ID(s): Q8IHS2
PDB ID(s): None
Isoelectric Point: 5.69
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000594 | THIF-type NAD/FAD binding fold |
| InterPro | IPR035985 | Ubiquitin-activating enzyme |
| PFam | PF00899 | THIF-type NAD/FAD binding fold |
| Superfamily | SSF69572 | Ubiquitin-activating enzyme |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 20 | 6 | 25 |
| disruptive | 2 | 19 | 28 | 34 |
| missense | 2 | 18 | 27 | 30 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 38 | 13 | 31 |
| disruptive | 6 | 76 | 40 | 91 |
| missense | 3 | 64 | 32 | 64 |
PlasmoDB Total SNPs: 146
Non-coding: 131 | Synonymous: 12 | Nonsynonymous: 3 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23943616 | Identification of biochemically distinct properties of the smallubiquitin-related modifier (SUMO) conjugation pathway in Plasmodium falciparum. | Reiter K, Mukhopadhyay D, ..., Matunis MJ | 10.1074/jbc.M113.498410 |