PF3D7_1144800

Genome location: Pf3D7_11_v3:1,774,605..1,776,787(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	not expressed	0.16	0.90
Schizont	not expressed	0.05	0.97
Gametocyte	expressed	1.44	0.42

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1144800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.204 | MFS: -2.694 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0904200)

Relative Growth Rate: 1.01 ± 0.10
Confidence: 6.02

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0904200)

Modification: Disrupted | RMgm-2490

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHR9

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=1.30) with 3A4M (Global RMSD=17.86)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_162857

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	30	18	45
disruptive	32	170	76	158
missense	22	133	65	130

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	63	22	47
disruptive	68	285	102	208
missense	42	230	90	146

PlasmoDB Total SNPs: 215

Non-coding: 75 | Synonymous: 79 | Nonsynonymous: 61 | Stop Codon: 0

Protein Information

Protein Length: 658 | Molecular Weight (kDa): 78.137

UniProt ID(s): Q8IHR9

PDB ID(s): None

Isoelectric Point: 8.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011004	Trimeric LpxA-like superfamily
InterPro	IPR018357	Hexapeptide transferase, conserved site
PFam	N/A	N/A
Superfamily	SSF51161	Trimeric LpxA-like superfamily