PF3D7_1145000

Genome location: Pf3D7_11_v3:1,780,084..1,782,733(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.04	0.97
Schizont	not expressed	0.32	0.82
Gametocyte	not expressed	0.30	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1145000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.995 | MFS: -1.41 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0904000)

Relative Growth Rate: 0.99 ± 0.06
Confidence: 6.95

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0904000)

Modification: Disrupted | RMgm-2488

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHR7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533265

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	44	23	46
disruptive	16	115	65	156
missense	15	111	61	149

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	92	26	53
disruptive	40	248	108	192
missense	32	223	90	130

PlasmoDB Total SNPs: 198

Non-coding: 145 | Synonymous: 22 | Nonsynonymous: 31 | Stop Codon: 0

Protein Information

Protein Length: 577 | Molecular Weight (kDa): 68.283

UniProt ID(s): Q8IHR7

PDB ID(s): None

Isoelectric Point: 10.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A