Genome location: Pf3D7_11_v3:1,782,875..1,787,222(-)
Genome classification: Core
Product Description: coatomer subunit gamma, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030126 | COPI vesicle coat |
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0000139 | Golgi membrane |
| Component | GO:0005829 | cytosol |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| Component | GO:0016020 | membrane |
| Component | GO:0005634 | nucleus |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0006891 | intra-Golgi vesicle-mediated transport |
| Process | GO:0009306 | protein secretion |
| Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.37 | 0.82 |
| Trophozoite | expressed | 0.42 | 0.74 |
| Schizont | expressed | 0.44 | 0.72 |
| Gametocyte | possibly expressed | 0.33 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1145100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.133 | MFS: -3.165 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0903900)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0903900)
Modification: Disrupted | RMgm-2487
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHR6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101348
Most Similar Human Ortholog: Q9UBF2
TM-align score: 0.67 | RMSD: 4.90
Seq Identity: 0.34 | Length: 657 / 1068
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000158623 | COPI coat complex subunit gamma 2 |
| ENSG00000181789 | COPI coat complex subunit gamma 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 70 | 53 | 96 |
| disruptive | 19 | 90 | 66 | 142 |
| missense | 11 | 84 | 63 | 116 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 27 | 166 | 63 | 86 |
| disruptive | 31 | 219 | 118 | 255 |
| missense | 22 | 187 | 98 | 181 |
PlasmoDB Total SNPs: 238
Non-coding: 165 | Synonymous: 53 | Nonsynonymous: 20 | Stop Codon: 0
Protein Length: 1068 | Molecular Weight (kDa): 124.369
UniProt ID(s): Q8IHR6
PDB ID(s): None
Isoelectric Point: 6.84
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002553 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| InterPro | IPR009028 | Coatomer/calthrin adaptor appendage, C-terminal subdomain |
| InterPro | IPR013040 | Coatomer, gamma subunit, appendage, Ig-like subdomain |
| InterPro | IPR013041 | Clathrin adaptor, appendage, Ig-like subdomain superfamily |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR017106 | Coatomer gamma subunit |
| InterPro | IPR032154 | Coatomer subunit gamma, C-terminal |
| PFam | PF01602 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| PFam | PF08752 | Coatomer, gamma subunit, appendage, Ig-like subdomain |
| PFam | PF16381 | Coatomer subunit gamma, C-terminal |
| Superfamily | SSF48371 | Armadillo-type fold |
| Superfamily | SSF49348 | Clathrin adaptor, appendage, Ig-like subdomain superfamily |
| Superfamily | SSF55711 | Coatomer/calthrin adaptor appendage, C-terminal subdomain |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 11493663 | Three dimensional configuration of the secretory pathway and segregation ofsecretion granules in the yeast Saccharomyces cerevisiae | Rambourg A, Jackson CL, Clermont Y | 10.1242/jcs.114.12.2231 |
| 7929113 | Yeast beta- and beta'-coat proteins (COP). Two coatomer subunits essential forendoplasmic reticulum-to-Golgi protein traffic | Duden R, Hosobuchi M, ..., Schekman R | https://pubmed.ncbi.nlm.nih.gov/7929113/ |
| 7926789 | Large-scale analysis of gene expression, protein localization, and genedisruption in Saccharomyces cerevisiae | Burns N, Grimwade B, ..., Snyder M | 10.1101/gad.8.9.1087 |
| 7810913 | Ultrastructural modifications of vesicular and Golgi elements in theSaccharomyces cerevisiae sec21 mutant at permissive and non-permissivetemperatures | Rambourg A, Clermont Y, Jackson CL, Kepes F | 10.1002/ar.1092400104 |
| 8070655 | BFR1, a multicopy suppressor of brefeldin A-induced lethality, is implicated insecretion and nuclear segregation in Saccharomyces cerevisiae | Jackson CL, Kepes F | 10.1093/genetics/137.2.423 |
| 12925749 | Suppression of coatomer mutants by a new protein family with COPI and COPIIbinding motifs in Saccharomyces cerevisiae | Sandmann T, Herrmann JM, ..., Spang A | 10.1091/mbc.e02-11-0736 |
| 8253840 | Retrograde lipid traffic in yeast: identification of two distinct pathways forinternalization of fluorescent-labeled phosphatidylcholine from the plasmamembrane | Kean LS, Fuller RS, Nichols JW | 10.1083/jcb.123.6.1403 |
| 11260526 | Dsl1p, an essential protein required for membrane traffic at the endoplasmicreticulum/Golgi interface in yeast | Vanrheenen SM, Reilly BA, Chamberlain SJ, Waters MG | 10.1034/j.1600-0854.2001.020307.x |
| 9927415 | Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteinswith overlapping function | Poon PP, Cassel D, ..., Johnston GC | 10.1093/emboj/18.3.555 |
| 9639310 | The Saccharomyces cerevisiae early secretion mutant tip20 is synthetic lethalwith mutants in yeast coatomer and the SNARE proteins Sec22p and Ufe1p | Frigerio G | 10.1002/(SICI)1097-0061(199805)14:7<633::AID-YEA267>3.0.CO;2-3 |
| 9580559 | Recycling of the yeast v-SNARE Sec22p involves COPI-proteins and the ERtransmembrane proteins Ufe1p and Sec20p | Ballensiefen W, Ossipov D, Schmitt HD | 10.1242/jcs.111.11.1507 |
| 28235825 | Genome-Wide Screen Reveals sec21 Mutants of Saccharomyces cerevisiae AreMethotrexate-Resistant | Wong LH, Flibotte S, ..., Nislow C | 10.1534/g3.116.038117 |
| 9049245 | COPI-independent anterograde transport: cargo-selective ER to Golgi proteintransport in yeast COPI mutants | Gaynor EC, Emr SD | 10.1083/jcb.136.4.789 |
| 10547350 | The sorting determinant guiding Hsp150 to the COPI-independent transport pathwayin yeast | Suntio T, Shmelev A, Lund M, Makarow M | 10.1242/jcs.112.22.3889 |