PF3D7_1145200

Genome location: Pf3D7_11_v3:1,788,846..1,798,269(-)

Genome classification: Core

Function and Localization

Product Description: serine/threonine protein kinase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.7.11.1 (Non-specific serine/threonine protein kinase)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.09	0.96
Trophozoite	not expressed	0.10	0.94
Schizont	expressed	2.41	0.24
Gametocyte	expressed	1.15	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1145200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.278 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0903800)

Relative Growth Rate: 0.14 ± 0.16
Confidence: 5.07

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHR5

"Best" AlphaFill ligand hit: PGO (s-1,2-propanediol, Local RMSD=0.26) with 3BQR (Global RMSD=7.40)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
2.7.11.1	non-specific serine/threonine protein kinase	ATPKClDTTP53DRBEDTATBCAKN-93K252aCKI-7LAALSTAACS...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_148535

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	30	165	69	173
disruptive	149	567	260	549
missense	83	404	196	425

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	55	317	111	168
disruptive	289	1007	367	588
missense	157	753	274	395

PlasmoDB Total SNPs: 626

Non-coding: 348 | Synonymous: 124 | Nonsynonymous: 154 | Stop Codon: 0

Protein Information

Protein Length: 2015 | Molecular Weight (kDa): 238.765

UniProt ID(s): Q8IHR5

PDB ID(s): None

Isoelectric Point: 6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000719	Protein kinase domain
InterPro	IPR011009	Protein kinase-like domain superfamily
InterPro	IPR017441	Protein kinase, ATP binding site
PFam	PF00069	Protein kinase domain
Superfamily	SSF56112	Protein kinase-like domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104