PF3D7_1145300 (CRIPT)

Genome location: Pf3D7_11_v3:1,798,297..1,799,944(-)

Genome classification: Core

Function and Localization

Product Description: cysteine-rich PDZ-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0008017	microtubule binding
Process	GO:0031122	cytoplasmic microtubule organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	0.99
Trophozoite	no data	0.05	0.96
Schizont	no data	0.03	0.97
Gametocyte	no data	0.10	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1145300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.222 | MFS: -2.581 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0903700)

Relative Growth Rate: 1.05 ± 0.09
Confidence: 6.31

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0903700)

Modification: Disrupted | RMgm-2485

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3G5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104550

Most Similar Human Ortholog: Q9P021

TM-align score: 0.66 | RMSD: 2.70

Seq Identity: 0.36 | Length: 74 / 87

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000119878	CXXC repeat containing interactor of PDZ3 domain

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	1
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	2
missense	0	0	0	0

PlasmoDB Total SNPs: 124

Non-coding: 113 | Synonymous: 10 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 87 | Molecular Weight (kDa): 9.931

UniProt ID(s): C6S3G5

PDB ID(s): None

Isoelectric Point: 9.62

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019367	PDZ-binding protein, CRIPT
PFam	PF10235	PDZ-binding protein, CRIPT
Superfamily	N/A	N/A