Genome location: Pf3D7_11_v3:1,800,111..1,804,509(-)
Genome classification: Core
Product Description: dynamin-like protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0020020 | food vacuole |
| Component | GO:0030430 | host cell cytoplasm |
| Component | GO:0016020 | membrane |
| Component | GO:0031965 | nuclear membrane |
| Component | GO:0005634 | nucleus |
| Component | GO:0005886 | plasma membrane |
| Component | GO:0020005 | symbiont-containing vacuole membrane |
| Function | GO:0003924 | GTPase activity |
| Function | GO:0003723 | RNA binding |
| Function | GO:0008017 | microtubule binding |
| Process | GO:0000266 | mitochondrial fission |
| Process | GO:0048285 | organelle fission |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.24 | 0.88 |
| Trophozoite | expressed | 0.65 | 0.63 |
| Schizont | expressed | 1.16 | 0.46 |
| Gametocyte | expressed | 0.62 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1145400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.055 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHR4
"Best" AlphaFill ligand hit: GNH (aminophosphonic acid-guanylate ester, Local RMSD=0.04) with 3W6N (Global RMSD=4.32)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P39052 | Dynamin-2 | Rattus norvegicus | HOGENOM | CHEMBL3329968CHEMBL2312430 |
Protein Length: 837 | Molecular Weight (kDa): 96.374
PDB ID(s): None
Isoelectric Point: 8.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000375 | Dynamin central domain |
| InterPro | IPR001401 | Dynamin, GTPase domain |
| InterPro | IPR003130 | Dynamin GTPase effector |
| InterPro | IPR019762 | Dynamin, GTPase region, conserved site |
| InterPro | IPR022812 | Dynamin superfamily |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00350 | Dynamin superfamily |
| PFam | PF01031 | Dynamin central domain |
| PFam | PF02212 | Dynamin GTPase effector |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 18 | 56 | 22 | 63 |
| disruptive | 10 | 46 | 25 | 57 |
| missense | 4 | 38 | 20 | 48 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 31 | 107 | 36 | 63 |
| disruptive | 27 | 85 | 73 | 173 |
| missense | 11 | 67 | 53 | 106 |
PlasmoDB Total SNPs: 174
Non-coding: 143 | Synonymous: 22 | Nonsynonymous: 9 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15240099 | Isolation and functional characterization of a dynamin-like gene from Plasmodiumfalciparum. | Li H, Han Z, ..., Wang H | 10.1016/j.bbrc.2004.06.010 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 19719972 | Dynamin like protein 1 participated in the hemoglobin uptake pathway ofPlasmodium falciparum. | Zhou HC, Gao YH, Zhong X, Wang H | https://pubmed.ncbi.nlm.nih.gov/19719972/ |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 34739032 | Tubulin isotypes optimize distinct spindle positioning mechanisms during yeast mitosis | Nsamba ET, Bera A, ..., Gupta ML | 10.1083/jcb.202010155 |
| 37540724 | Immunogenic mapping of rDyn-1 and rKDDR-plus proteins and selection of oligopeptides by immunoblotting for the diagnosis of Leishmania infantum-infecteddogs | Siqueira WF, Cardoso MS, ..., Fujiwara RT | 10.1371/journal.pntd.0011535 |
| 35064377 | Lipopolysaccharide Accelerates Neuropilin-1 Protein Degradation by Activating the Large GTPase Dynamin-1 in Macrophages | Wu S, Huang Y, Huang X, Dai X | 10.1007/s10753-021-01610-z |
| 37790502 | Dynamin 1xA interacts with Endophilin A1 via its spliced long C-terminus for ultrafast endocytosis | Imoto Y, Xue J, ..., Robinson PJ | 10.1101/2023.09.21.558797 |
| 37181046 | The dynamin GTPase mediates regenerative axonal fusion in Caenorhabditis elegans by regulating fusogen levels | Vijayaraghavan T, Dhananjay S, ..., Neumann B | 10.1093/pnasnexus/pgad114 |
| 34428626 | Molecular basis of synchronous replication of malaria parasites in the blood stage | Dos Santos BM, Pereira PH, Garcia CR | 10.1016/j.mib.2021.08.002 |