PF3D7_1145500 (ABCB3)

Genome location: Pf3D7_11_v3:1,807,031..1,810,365(+)

Genome classification: Core

Function and Localization

Product Description: ABC transporter B family member 3, putative

SignalP Peptide: MRNYGLLHFLLVLLLLNLSIKS

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1145500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.269 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0904900)

Modification: Disrupted | RMgm-4775

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHR3

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.08) with 5D3M (Global RMSD=5.19)

Orthology to BindingDB Entries:

Orthology Information

Ortholog Group (OrthoMCL): OG6_163871

No human ortholog(s)

Protein Information

Protein Length: 833 | Molecular Weight (kDa): 99.349

UniProt ID(s): A0A060CT48, A0A060CT89, A0A060CW66, A0A060CWQ3, A0A060CWQ8, A0A060CWR5, A0A060CX13, A0A060D1W9, A0A060D223, A0A5J6C3S0, A0A5J6C3Y3, A0A5J6C4P9, A0A5J6C4T2, A0A5J6C509, A0A5J6C6A9, A0A5J6C7Y6, I6Q0Z2, I6Q2L1, I6Q5H4, Q8IHR3

PDB ID(s): None

Isoelectric Point: 10.25

Protein Domain Annotations:

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 151

Non-coding: 97 | Synonymous: 27 | Nonsynonymous: 27 | Stop Codon: 0