Product Description: TMEM65 domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.23 | 0.86 |
| Schizont | expressed | 0.19 | 0.88 |
| Gametocyte | expressed | 0.61 | 0.67 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1145600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.241 | MFS: -2.714 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZYV4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104678
Most Similar Human Ortholog: Q6PI78
TM-align score: 0.57 | RMSD: 2.87
Seq Identity: 0.37 | Length: 153 / 629
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000164983 | transmembrane protein 65 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 52 | 20 | 43 |
| disruptive | 14 | 90 | 51 | 143 |
| missense | 11 | 86 | 48 | 136 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 83 | 35 | 57 |
| disruptive | 39 | 218 | 108 | 168 |
| missense | 23 | 195 | 93 | 122 |
PlasmoDB Total SNPs: 133
Non-coding: 55 | Synonymous: 47 | Nonsynonymous: 30 | Stop Codon: 1
Protein Length: 629 | Molecular Weight (kDa): 74.597
UniProt ID(s): A0A143ZYV4
PDB ID(s): None
Isoelectric Point: 10.18
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR019537 | Transmembrane protein 65 |
| PFam | PF10507 | Transmembrane protein 65 |
| Superfamily | SSF55781 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 24841368 | Identifying novel cell cycle proteins in Apicomplexa parasites throughco-expression decision analysis. | Butler CL, Lucas O, ..., White M | 10.1371/journal.pone.0097625 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |