PF3D7_1145700

Genome location: Pf3D7_11_v3:1,812,871..1,814,731(+)

Genome classification: Core

Function and Localization

Product Description: bicoid-interacting protein BIN3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.1.1.- (Methyltransferases.)

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0008171	O-methyltransferase activity
Function	GO:0008173	RNA methyltransferase activity
Function	GO:0017069	snRNA binding
Process	GO:0040031	snRNA modification

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	not expressed	0.20	0.87
Schizont	possibly expressed	0.19	0.87
Gametocyte	not expressed	0.36	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1145700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -3.049 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHR1

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
2.1.1.-	Ex: homocysteine S-methyltransferase	EDTACTABNickelA9145CtylosintacrineTween 80FTI-2628macrocinadenosineRelomycinphosphate...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103556

Most Similar Human Ortholog: Q7L2J0

TM-align score: 0.56 | RMSD: 3.20

Seq Identity: 0.25 | Length: 241 / 384

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000146834	methylphosphate capping enzyme

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	26	6	16
disruptive	20	61	29	82
missense	14	52	24	70

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	40	14	25
disruptive	33	137	58	164
missense	22	104	44	106

PlasmoDB Total SNPs: 118

Non-coding: 73 | Synonymous: 24 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 384 | Molecular Weight (kDa): 46.253

UniProt ID(s): Q8IHR1

PDB ID(s): None

Isoelectric Point: 9.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR010675	RNA methyltransferase bin3, C-terminal
InterPro	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase
InterPro	IPR039772	RNA methyltransferase Bin3-like
PFam	PF06859	RNA methyltransferase bin3, C-terminal
Superfamily	SSF53335	S-adenosyl-L-methionine-dependent methyltransferase