PF3D7_1145800

Genome location: Pf3D7_11_v3:1,814,738..1,818,029(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.38	0.81
Trophozoite	possibly expressed	0.44	0.75
Schizont	not expressed	0.08	0.95
Gametocyte	not expressed	0.69	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1145800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.203 | MFS: -2.592 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHR0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110837

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	63	42	69
disruptive	44	192	86	166
missense	35	170	76	147

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	32	135	47	67
disruptive	98	353	133	257
missense	69	301	114	167

PlasmoDB Total SNPs: 229

Non-coding: 111 | Synonymous: 66 | Nonsynonymous: 52 | Stop Codon: 0

Protein Information

Protein Length: 915 | Molecular Weight (kDa): 108.956

UniProt ID(s): Q8IHR0

PDB ID(s): None

Isoelectric Point: 8.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A