About Gene List

PF3D7_1145900

Genome location: Pf3D7_11_v3:1,818,370..1,820,937(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.99
Trophozoite not expressed 0.06 0.96
Schizont not expressed 0.04 0.97
Gametocyte not expressed 0.50 0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1145900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.662 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A1Q0

"Best" AlphaFill ligand hit: NDP (nadph dihydro-nicotinamide-adenine-dinucleotide phosphate, Local RMSD=0.03) with 3JSU (Global RMSD=21.51)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533183

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 20 6 28
disruptive 12 59 25 70
missense 12 58 25 68

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 34 18 24
disruptive 20 107 42 86
missense 19 100 41 65

PlasmoDB Total SNPs: 173

Non-coding: 147 | Synonymous: 19 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 294 | Molecular Weight (kDa): 35.386

UniProt ID(s): A0A144A1Q0

PDB ID(s): None

Isoelectric Point: 9.32

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094