About Gene List

PF3D7_1146100

Genome location: Pf3D7_11_v3:1,823,963..1,826,025(-)

Genome classification: Core

Function and Localization

Product Description: PH-like domain-containing protein, putative

SignalP Peptide: MKCLIFCFSIFLLLTLSLC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0044312 crystalloid

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.01 0.99
Trophozoite possibly expressed 0.03 0.98
Schizont possibly expressed 0.01 0.99
Gametocyte not expressed 0.54 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1146100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.142 | MFS: -2.886 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0902900)

Modification: Tagged | RMgm-4864

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHQ7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_148526

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 17 7 12
disruptive 6 23 11 38
missense 6 23 11 33

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 34 8 10
disruptive 11 45 31 57
missense 8 43 24 33

PlasmoDB Total SNPs: 176

Non-coding: 161 | Synonymous: 11 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 175 | Molecular Weight (kDa): 20.304

UniProt ID(s): Q8IHQ7

PDB ID(s): None

Isoelectric Point: 4.75

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily SSF50729 N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
32736136 Plasmodium berghei LAPs form an extended protein complex that facilitatescrystalloid targeting and biogenesis. Tremp AZ, Saeed S, ..., Dessens JT 10.1016/j.jprot.2020.103925