PF3D7_1146500 (LRR10)

Genome location: Pf3D7_11_v3:1,830,464..1,831,417(+)

Genome classification: Core

Function and Localization

Product Description: leucine-rich repeat protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol
Function	GO:0004385	guanylate kinase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.13	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1146500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.774 | MFS: -1.133 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0902600)

Relative Growth Rate: 1.02 ± 0.10
Confidence: 6.01

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0902600)

Modification: Disrupted | RMgm-2484

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHQ3

"Best" AlphaFill ligand hit: URI (uridine, Local RMSD=0.89) with 4R07 (Global RMSD=7.81)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105510

Most Similar Human Ortholog: C9JKE8

TM-align score: 0.71 | RMSD: 2.45

Seq Identity: 0.21 | Length: 184 / 317

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000010626	leucine rich repeat containing 23

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	6	3	18
disruptive	11	44	17	40
missense	10	29	17	32

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	18	10	34
disruptive	38	68	36	98
missense	22	53	28	56

PlasmoDB Total SNPs: 60

Non-coding: 0 | Synonymous: 36 | Nonsynonymous: 24 | Stop Codon: 0

Protein Information

Protein Length: 317 | Molecular Weight (kDa): 37.423

UniProt ID(s): Q2TFW2, Q8IHQ3

PDB ID(s): None

Isoelectric Point: 6.9

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF52058	N/A