Product Description: kinesin-X4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005871 | kinesin complex |
| Component | GO:0005874 | microtubule |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0008017 | microtubule binding |
| Function | GO:0003777 | microtubule motor activity |
| Process | GO:0007018 | microtubule-based movement |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.00 | 1.00 |
| Trophozoite | not expressed | 0.00 | 1.00 |
| Schizont | not expressed | 0.01 | 0.99 |
| Gametocyte | possibly expressed | 0.30 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1146700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.591 | #Insertions: 4
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0902400)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0902400)
Modification: Tagged | RMgm-5026
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IHQ1
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.21) with 2OWM (Global RMSD=4.05)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 47 | 31 | 60 |
| disruptive | 28 | 115 | 67 | 132 |
| missense | 25 | 105 | 63 | 117 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 102 | 38 | 56 |
| disruptive | 53 | 262 | 103 | 235 |
| missense | 35 | 225 | 88 | 162 |
PlasmoDB Total SNPs: 197
Non-coding: 137 | Synonymous: 27 | Nonsynonymous: 33 | Stop Codon: 0
Protein Length: 802 | Molecular Weight (kDa): 95.574
UniProt ID(s): Q8IHQ1
PDB ID(s): None
Isoelectric Point: 9.8
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001752 | Kinesin motor domain |
| InterPro | IPR019821 | Kinesin motor domain, conserved site |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR027640 | Kinesin-like protein |
| PFam | PF00225 | Kinesin motor domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 35900985 | Genome-wide functional analysis reveals key roles for kinesins in the mammalianand mosquito stages of the malaria parasite life cycle. | Zeeshan M, Rashpa R, ..., Tewari R | 10.1371/journal.pbio.3001704 |