PF3D7_1146800

Genome location: Pf3D7_11_v3:1,843,205..1,854,563(-)

Genome classification: Core

Function and Localization

Product Description: female development protein FD2, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.04	0.98
Schizont	not expressed	0.04	0.98
Gametocyte	expressed	1.41	0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1146800

Resistome Missense Mutations: N2236D

Resistome Compounds with Missense Mutations: GNF-Pf-3600

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.589 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0902300)

Modification: Tagged | RMgm-5362

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533487

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	36	188	84	205
disruptive	166	687	334	733
missense	98	540	280	580

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	79	341	137	230
disruptive	336	1414	512	1075
missense	201	1051	401	661

PlasmoDB Total SNPs: 555

Non-coding: 121 | Synonymous: 267 | Nonsynonymous: 166 | Stop Codon: 1

Protein Information

Protein Length: 3188 | Molecular Weight (kDa): 375.412

UniProt ID(s): Q8IHQ0

PDB ID(s): None

Isoelectric Point: 5.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A