PF3D7_1146900

Genome location: Pf3D7_11_v3:1,855,488..1,857,930(+)

Genome classification: Core

Function and Localization

Product Description: protein YIPF6, putative

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0016192	vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.02	0.99
Trophozoite	no data	0.05	0.96
Schizont	no data	0.02	0.98
Gametocyte	no data	0.06	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1146900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.565 | MFS: -2.48 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3G6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102338

Most Similar Human Ortholog: Q96EC8

TM-align score: 0.83 | RMSD: 2.05

Seq Identity: 0.29 | Length: 169 / 185

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000181704	Yip1 domain family member 6

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	9	7	12
disruptive	1	16	5	30
missense	1	15	4	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	17	10	12
disruptive	5	44	23	51
missense	3	32	18	35

PlasmoDB Total SNPs: 175

Non-coding: 159 | Synonymous: 12 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 185 | Molecular Weight (kDa): 21.802

UniProt ID(s): C6S3G6

PDB ID(s): None

Isoelectric Point: 8.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006977	Yip1 domain
PFam	PF04893	Yip1 domain
Superfamily	N/A	N/A