PF3D7_1147100

Genome location: Pf3D7_11_v3:1,870,415..1,871,077(-)

Genome classification: Core

Function and Localization

Product Description: dynein light chain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.00	1.00
Schizont	no data	0.03	0.98
Gametocyte	no data	0.66	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1147100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.698 | MFS: -3.542 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0933600)

Relative Growth Rate: 1.00 ± 0.10
Confidence: 6.01

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0902000)

Modification: Disrupted | RMgm-2479

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3G7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101459

Most Similar Human Ortholog: Q8WW35

TM-align score: 0.85 | RMSD: 1.75

Seq Identity: 0.20 | Length: 100 / 102

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000213123	Tctex1 domain containing 2
ENSG00000272741	novel protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	12	5	6
disruptive	0	11	10	17
missense	0	11	10	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	18	2	7
disruptive	5	23	8	25
missense	3	21	8	21

PlasmoDB Total SNPs: 20

Non-coding: 17 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 102 | Molecular Weight (kDa): 12.067

UniProt ID(s): C6S3G7

PDB ID(s): None

Isoelectric Point: 9.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005334	Dynein light chain Tctex-1 like
PFam	PF03645	Dynein light chain Tctex-1 like
Superfamily	N/A	N/A