About Gene List

PF3D7_1147300

Genome location: Pf3D7_11_v3:1,882,167..1,888,573(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.15 0.93
Trophozoite expressed 1.19 0.42
Schizont expressed 0.61 0.67
Gametocyte expressed 0.70 0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1147300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.1 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0901800)

  • Relative Growth Rate: 0.91 ± 0.20
  • Confidence: 4.65

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0901800)

Modification: Disrupted | RMgm-2478

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHP7

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=8.79) with 4M37 (Global RMSD=9.65)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_151681

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 77 35 73
disruptive 38 228 91 229
missense 35 221 87 217

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 23 137 53 86
disruptive 87 409 155 304
missense 71 372 144 236

PlasmoDB Total SNPs: 234

Non-coding: 116 | Synonymous: 64 | Nonsynonymous: 54 | Stop Codon: 0

Protein Information

Protein Length: 1361 | Molecular Weight (kDa): 158.898

UniProt ID(s): Q8IHP7

PDB ID(s): None

Isoelectric Point: 7.61

Protein Domain Annotations:

Source Family ID Description
InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
PFam N/A N/A
Superfamily SSF53335 S-adenosyl-L-methionine-dependent methyltransferase

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596