PF3D7_1147400

Genome location: Pf3D7_11_v3:1,888,273..1,889,408(-)

Genome classification: Core

Function and Localization

Product Description: COX2 transmembrane domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005965	protein farnesyltransferase complex
Function	GO:0004660	protein farnesyltransferase activity
Function	GO:0008270	zinc ion binding
Process	GO:0018343	protein farnesylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.03	0.98
Schizont	no data	0.05	0.96
Gametocyte	no data	0.06	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1147400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.153 | MFS: -2.944 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0901700)

Relative Growth Rate: 0.08 ± 0.04
Confidence: 8.05

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3G8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146116

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 53

Non-coding: 51 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 77 | Molecular Weight (kDa): 9.047

UniProt ID(s): C6S3G8

PDB ID(s): None

Isoelectric Point: 10.1

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036257	Cytochrome C oxidase subunit II, transmembrane domain superfamily
PFam	N/A	N/A
Superfamily	SSF81464	Cytochrome C oxidase subunit II, transmembrane domain superfamily