PF3D7_1147600

Genome location: Pf3D7_11_v3:1,893,348..1,896,529(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	expressed	0.32	0.81
Schizont	expressed	0.28	0.83
Gametocyte	possibly expressed	0.57	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1147600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.868 | MFS: -1.676 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0901500)

Relative Growth Rate: 1.00 ± 0.09
Confidence: 6.15

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0901500)

Modification: Disrupted | RMgm-2475

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IHP5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532601

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	32	16	27
disruptive	13	55	33	63
missense	7	52	31	51

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	53	23	41
disruptive	26	123	62	162
missense	14	103	45	89

PlasmoDB Total SNPs: 208

Non-coding: 151 | Synonymous: 44 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 596 | Molecular Weight (kDa): 71.65

UniProt ID(s): Q8IHP5

PDB ID(s): None

Isoelectric Point: 4.77

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094